Abstract
Background and Objectives: Pathogenesis of cholesteatoma is characterized by cellular proliferation, differentiation, and programmed cell death of keratinizing epithelium in the middle ear cavity. This study was performed to investigate the role of Heat-shock protein 60 and 70 (HSP60 and 70) in the pathogenesis of cholesteatoma. Materials and Methods: Cholesteatoma samples were taken from 7 patients during operation. Immunohistochemical stain was used for HSP 60 and HSP 70. External ear canal skin and ear drum were used as a control group. Results: HSP60 is detected in all cases and HSP 70 is detected in 5 cases in all layers of cholesteatoma epithelium from the junction between drum and cholesteatoma. HSP60 and HSP70 are not detected in the skin of external ear canal and ear drum. Conclusion: HSP60 and HSP70 may have integral role in the pathogenesis of acquired cholesteatoma and we suggest abnormal hyperplasia of epithelial cells as a pathogenesis of acquired cholesteatoma. (J Clinical Otolaryngol 2002;13:188–198)
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