Abstract
Abstract The Effects of Hataedock on 2,4-dinitrofluorobenzeneInduced Atopic Dermatitis Like Skin Lesion in NC/Nga Mice Cha Ho Yeol 1 ･ Ahn Sang Hyun 2 ･ Jeong A Ram 1 ･ Cheon Jin Hong 1 ･ Park Sun Young 3 ･ Kim Ki Bong 11 Department of Pediatrics of Korean Medicine, Pusan National University Hospital 2 Research Institute for Korean Medicine, Pusan National University 3 Department of physiology, college of Korean Medicine, Semyung University Objectives Hataedock is the treatment that dispels toxic heat and meconium gathered at the fetus for the new born baby by orally administered herbal extracts. The purpose of this study was to evaluate whether Hataedock alleviate inflammatory skin damages in AD-induced NC/Nga mice through regulating of skin barrier maintain and Th2 differentiation. Methods We established an AD model in the 3-week-old NC/Nga mice through the repeated application of DNFB (dinitrochlorobenzene) on days 28, 35, 42 after Hataedock treatment which was orally administered. We identified the changes of skin barrier and Th2 differentiation through the histological and immunohistochemical changes of protein kinase C (PKC), interleukin (IL)-4, degranulated mast cell, Substance P and MMP-9.
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