ՄԻԶԱՅԻՆ ՀԱՄԱԿԱՐԳԻ ԻՆԿՐՈՒՍՏԱՑԻԱՆԵՐԸ COVID-19-ՈՎ ՀԻՎԱՆԴՆԵՐԻ ՇՐՋԱՆՈՒՄ (ՏԵՍՈՒԹՅԱՆ ՎԵՐԼՈՒԾՈՒԹՅՈՒՆ)

Abstract

Since 11.03.2020 the World Health Organization has declared the coronavirus disease (COVID-19) caused by a new type of coronavirus (SARS CoV-2) as a global pandemic. Coronaviruses are single-stranded RNA viruses divided into four main classes: A, B, C, and D. SARS CoV-2 is an RNA beta-coronavirus. The most common complication of the disease is the bilateral viral pneumonia, which leads to respiratory failure in many patients. COVID-19 is multisystemic in nature and can cause damage to almost any human organ. The organs of the urinary system are no exception. SARS-CoV-2 has a specific three-dimensional protein structure characterized by a strong binding to the angiotensin-converting enzyme 2 (ACE2) receptor. Under these conditions, ACE2-producing human organs can act as target cells for SARS-CoV-2. Encrusted cystitis is a rare pathology, the main cause of which is urinary infection, especially with the urea-splitting bacteria. C. urealyticum is a gram-positive bacterium that causes alkalinization of the urine by breaking down urea to ammonia. The disease is characterized by calcification of the bladder mucosa. In our opinion, encrusted cystitis can be considered as a complication of the new coronavirus infection. Its pathogenetic basis is probably the affinity of SARS CоV-2 to ACE2 receptors in the urothelium. Thus, summarizing the results obtained from the researches carried out by various authors, we conclude that no descriptive work has been done on the course, clinical picture, treatment results, as well as the features of the pathological picture of encrusted cystitis associated with COVID-19. In this case, new studies with a larger number of patients are needed, which will enable not only to evaluate the results of individual methods, but also to perform an analysis of these results. In our opinion, encrusted cystitis can be considered as a complication of novel coronavirus infection. Taking into account the aforementioned, there is a need to work on the discussed problems.