Abstract
ARAKI has reported a possibility to diagnose the my cardial damage serologically by means of the myocardium phosphatide flocculation test (CCR), and HANGER has reported that the cephalin-cholesterol flocculation test (CCF) is a sensitive indicator of parenchymal liver cell damage. The auther divided bovine myocardum phospatide into cephalin which is insoluble in cold pure alcohol but soluble in ether and lecithin which is soluble in cold pure alcohol, and studied on the myocardium cephalin-cholesterol floculation reaction (CCR) to know the possibility to diagnose myocardial damge. The results of CCR were compared with the findings of ECG. Further I carried out the quantitative analysis of myocardium cephalin in patient's serum serologically by the myocardium cephalin precipitation reaction (ACCR) using anti myocardium cephalin rabbit sera.127 patients were subjected to these tests. 50 of 55 patients with myocardial damage revealed by ECG showed positive result by CCR and 5 patients negative. 41 of 72 patients without myocardual damage showed negative and 31 patients positive. Namely in 91 of 127 patients (71.6%) the result of CCR was identical with the finding of ECG, but for the purpose of the diagnosis of myocardial damage CCR was a sensitiver indicator than ECG. When CCR is carried out serially during the course of a disease, it will be a useful method to know the prognosis of myocardial damage. The result of CCR by human myocardium cephalin concided with that by bovine myocardium cephalin. This indicates that the myocardium cephalin has no species-specificity.A clear correlation between CCR and the myocardium lecithin-cholesterol flocculation reaction (CLR) was found, but CCR was sensitiver than CLR. There was a parallel relation between CCR and CPR, but 63% of the result of CPR coincided with the finding of ECG, therefore, CCR was a sensitiver indicator of myocardial damage than CPR. The results of CCR were correlated slightly with those of CCF.In patients who showed the positive reaction of CCR the titer 1 : 3200 of ACCR was mostly found, but in those who showed the negative the titer 1 : 2000 of ACCR was mostly found. The boundary precipitation titer between the positive and the negative reaction of CCR was 1 : 2400, but that between the patients with myocardial damage revealed by ECG and the normals was 1 : 3200. The quantity of myocardium cephalin in sera of patients with myocardial damage increased, namely, the high precipitation titer of ACCR was obtained. The antigen titer in the myocardium lecithin precipitation reaction (ACLR) was lower than that of ACCR, but there was a clear correlation between the both tests. These facts may be probably due to the incompletion of the division technique of cephalin from phosphatide.
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