Abstract
Відновлення популяцій ценобіонтів Bifi dobacterium spp., Lactobacillus spp. після терапії експериментального дисбіозу іммобілізованим пробіотиком Escherichia coli M-17, що зберігався за низьких температур
Highlights
The research aim was to study the impact of freezing down to – °C and subsequent incubation in the media, simulating gastric and duodenal juices on the viability of probiotic bacteria, combined with prebiotics and immobilized in alginate gel
Low temperatures and lyophilization are most frequently applied for a long-term storage of probiotics
Our purpose was to investigate the effect of low temperature storage on the ability of the probiotic strain E. coli M- immobilized in unmodified and modified alginate gels to restore eubiotics of the intestinal microbiocenosis
Summary
The research aim was to study the impact of freezing down to – °C and subsequent incubation in the media, simulating gastric and duodenal juices on the viability of probiotic bacteria, combined with prebiotics and immobilized in alginate gel. The studies on designing the novel dosage forms of probiotics and symbiotics, immobilized in gel carriers are currently in progress. Low temperatures and lyophilization are most frequently applied for a long-term storage of probiotics. Symbiotics (a mixture of bacteria with oligosaccharides) were immobilized in granules of % alginate gel by ionotropic gelation.
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