Abstract
Epigenetic mechanisms play a leading role in the regulation of gene expression and the coordination of biological processes, influencing the aging rate and the organism’s lifespan. An important role in the implementation of these mechanisms is played by small RNAs which suppress the activity of own targets through the RNA interference and provide the antiviral protection. Enoxacin is a unique inducer of RNA interference factors with potential geroprotective activity. Its effects have been identified to be mediated by miRNAs but other types of non-coding RNAs may also be involved. In this study, we have investigated the effect of enoxacin on the Drosophila melanogaster lifespan and first analyzed the contribution of Argonaute family genes to this effect which specifically ensure the biogenesis and functioning of miRNAs, siRNAs, and piRNAs.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
