저령차전자탕(豬苓車前子湯)이 βA와 LPS로 처리된 BV2 microglial cell에 미치는 영향

Abstract

Objectives : This research investigates the effect of the JCT extract regarding Alzheimer's disease. Methods : The effects of the JCT extract on IL-<TEX>$1{\beta}$</TEX>, IL-6, TNF-<TEX>${\alpha}$</TEX>, COX-2, NOS-II mRNA, APP mRNA, BACE mRNA, Nitric oxide(NO), and <TEX>${\beta}A$</TEX> protein production in the BV2 microglia cell lines treated with LPS and <TEX>${\beta}A$</TEX> were investigated. Results : 1. The JCT extract suppressed the expression of IL-<TEX>$1{\beta}$</TEX>, IL-6, TNF-<TEX>${\alpha}$</TEX>, COX-2, and NOS-II mRNA in BV2 microglial cell line treated with LPS and <TEX>${\beta}A$</TEX>. 2. The JCT extract suppressed the expression of BACE and APP mRNA in BV2 microglial cell line treated with LPS and <TEX>${\beta}A$</TEX>. 3. The JCT extract suppressed the expression of Nitric oxide(NO) in BV2 microglial cell line treated with LPS and <TEX>${\beta}A$</TEX>. 4. The JCT extract suppressed the expression of <TEX>${\beta}A$</TEX> protein production in BV2 microglial cell line treated with LPS and <TEX>${\beta}A$</TEX>. Conclusions : These results suggest that the JCT group may be effective for the treatment of Alzheimer's disease. Thus, JCT could be considered among the future therapeutic drugs indicated for the treatment of Alzheimer's disease.