Abstract
Due to the significant development of optical technologies and methods used for both noninvasive diagnostics (optical biopsy, tomography, etc.) and improvement of therapeutic protocols (photodynamic therapy, photothermal destruction, etc.), the increasing of the penetration depth of light into tissues is an urgent problem, which is solved using immersion agents, including hyperosmotic, such as glucose. Moreover, the determination of the quantitative characteristics of the diffusion of immersion agents in tissues is important. In this work, we determined the effective diffusion coefficient of a 40%-glucose solution in human gingival mucosa tissue in vitro, which was (4.1 ± 0.8) • 10-6 cm2/s. The method is based on recording the kinetics of changes in the diffuse reflection spectra and applying the free diffusion model.
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