Abstract
This study compared the anti-atherosclerosis effects of the long-term ingestion of 2,3-dihydroxybenzoic acid (2,3-DHBA) and 3,4-dihydroxybenzoic acid (3,4-DHBA). Six group diets [normal diet (ND), high-fat diet (HFD), 2,3- and 3,4-DHBA high and low diets] were administered to Sprague-Dawley rats for six weeks. The final body weights of the six groups were similar. The total cholesterol, high, and low-density lipoprotein cholesterol levels in the blood plasma of the HFD group were higher than those in the ND group. The plasma levels in the 2,3- and 3,4-DHBA groups were similar to those in the HFD group. HFD, 2,3- and 3,4-DHBA groups showed accumulation of lipid droplets in liver tissues, and the aorta of the HFD group was thicker than that of the ND group, but the recovered aortic thickness of 2,3- and 3,4-DHBA groups was similar to that of the ND group. In addition, in vitro and in vivo antioxidant activities were the highest in the 3,4-DHBA group. Therefore, the daily intake of 2,3-DHBA and 3,4-DHBA may have anti-atherosclerosis effects.
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