Abstract
Goal. The study of the content of cyclic nucleotides in the eye tissues both in normal and in experimental conditions of toxic-allergic uveitis and the assessment of their possible impact on the development of the pathological process. Material and methods. The concentration of cAMP and cGMP in the eye tissues of experimental animals (rabbits) was determined using standard Amerscham kits by radioimmune method. The samples were counted on a Mark III counter. The results were processed according to the Student's method. Results. A significant decrease in the concentration of cAMP in the cornea, retina and vasculature of the rabbit's eye was found, which significantly affects the processes of catabolism and energy production. The content of another messenger cGMP in the same tissues is also reduced, and this suppresses the processes of cell proliferation. Conclusion. The results obtained add significant new elements to the picture of uveitis development, which should be considered when developing sound approaches to its effective treatment. Key words: cyclic nucleotides, uveitis, regulation of metabolism, cAMP, cGMP, eye tissues.
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