Abstract
The newly developed Leukoreductive Apheresis System TERUSYS™ allows leukoreduction from platelet concentrates during the course of platelet collection. Seventy-two bags of leukoreduced apheresis platelets were obtained. Among them, 6 bags were filtered with leukoreduction filter IMUGARD III-PL under bedside filtration conditions after 3 days' storage to confirm that double filtration has no adverse effect on the quality of PC. Samples were taken before and after the filtration process, and daily up to 5 days' storage. Leukocyte counts, platelet count, β-thromboglobulin (β-TG), anaphylatoxins, histamine, fibrinopeptide A (FPA), cytokines and platelet storage properties were measured in all units.No bags showed more 1×105 leukocytes after filtration. Average platelet loss was 6% (n=7). High levels of β-TG and C3a were observed in samples stored for 3 and 5 days, but β-TG, C3a, C5a, histamine, FPA and cytokine values were comparable in pre- and post-filtration samples (n=7). With regard to platelet properties pH, hypotonic shock recovery and aggregation reaction results were acceptable for clinical use (n=10). Double filtration had no adverse effect on the quality of PC (n=6).These results suggest that filtration during the course of platelet collection is effective.
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