Сучасні маркери прогнозування прееклампсії

Abstract

Hypertensive disorders during pregnancy are one of the leading causes of maternal and perinatal morbidity and mortality worldwide. According to WHO, severe preeclampsia complicates from 2 to 8% of all pregnancies and in the structure of direct causes of maternal mortality still occupies 2 place and is about 14%. Preeclampsia remains one of the main causes of infant morbidity (640–780‰) and perinatal mortality (18–30‰). The search for clinical diagnostic markers that would allow high precision and specificity to determine the onset time of preeclampsia. None of the markers known today are alone capable of reliably confirming the development of preeclampsia. The prognostic model is an alternative basis for clinical practice that allows for the prediction of results and for timely decision-making on how to improve them. The practical recommendations of the world’s major profile organizations on the use of prognostic models are reviewed. The position of the key profile organizations on the prediction of pre-eclampsia at the present stage and the involvement of prognostic models in this study are investigated. The data of the conducted researches on the use of biochemical markers and their combination in predicting the development of preeclampsia were collected. The most promising prognostic models using anamnestic, instrumental data and biochemical marker results have been studied. The predictive value and specificity of these models for determining the early and late manifestation of preeclampsia, as well as their possible introduction into clinical practice, are presented. Key words: preeclampsia, prognosis, pregnancy, maternal mortality, hypertension, biochemical markers.