Abstract
We report a case of Rh-incompatible hemolytic disease of bizygotic twin new borns delivered from a Rh D and C-negative woman without a history of prior pregnancy or blood transfusion.The alloimmune hemolysis was caused by maternal anti-D (first baby) and anti D+C (second baby) alloantibodies, which were detected at 32 week's gestation by gel tests (Micro Typing System) and at 34 weeks by conventional agglutination tests with glass tubes. The former method was more sensitive than the latter for detecting red cell alloantibodies.This case suggests that hemolytic disease of the newborn can occur during a first pregnancy even in a woman without prior blood transfusion.
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