Abstract
Prostaglandin E1 (PGE1) has already been shown to improve vascular patency in experimental microvascular anastomosis. It is also widely used following clinical microvascular anastomosis. We designed a prospective study to compare the efficacy of Lipo PGE1 and PGE1-CD (PGE1-α-cyclodextrin) in 34 patients (14 free tissue transfers and 20 digital replantations). Dosage of Lipo PGE1 was 10μg daily for an average of 8 days and that of PGE1-CD was 120μg (60μg×2) for an average of 6 days. Success in microvascular anastomosis was evaluated by survival of the flap or replanted finger after 2 weeks. The success rate of free tissue transfers for the lipo PGE1 group was 100% and that of the PGE1-CD group was 75%. The success rate of digital replantations for the lipo PGE1 group was 88% and that of the PGE1-CD group was 75%. There was no significant difference between the two groups. Four of the 16 patients receiving PGE1-CD complained of vascular pain during injection, whereas, none complained of vascular pain in the group receiving lipo PGE1. Lipo PGE1 showed at least the same efficacy on patency after microvascular surgery as PGE1-CD with less vascular pain.
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