０．１％ケタミン微量持続点滴麻酔法 基礎的研究とその臨床応用

Abstract

This study evaluated a new method to use 0.1% Ketamine Hydrochloride solution as an ideal approach to anesthesia for small animals. The Ketamine HCL was used primarily as an analgesic rather than as an anesthetic agent. In this report we present the data from both our experimental study of 22 cases and clinical study of 1455 patients anesthetized with 0.1% Ketamine HCL by intravenous“Micro-Mini”drip administration technique. For the experimental study, 20 dogs and 2 cats were used. They were examined the general clinical symptoms and hemo-dynamics during the anesthesia.Among the 1455 patients of clinical study, the 1051 were dogs and the 404 were cats. Of the dogs, 491 were males and 560 were females. The average body weight was 9.59 kg. AS for the cats, the 144 were males and 260 were females. The average body weight was 3.28 kg. All of them were also anesthetized with the same method as the experimental study. The general symptoms, duration of anesthetic time and the dose of Ketamine HCL were carefully observed. This anesthetic method was applied to various surgical procedures. Both the experimental and the clinical studies showed an eminently desirable results. In case of the clinical application of 1051 dogs, the anesthetic average time was 64 minutes. The average does of ketamine HCL was 6.01 mg per kg (SD±4.638), 6.07 mg per kg per hour (SD±4.76) .In clinical case of 404 cats, the anesthetic average time was 55 minutes. The average dose of Katamine HCL was 9.21 mg per kg (SD±5.05), 11.16 mg per kg per hour (SD±6.19) . The total dose of Ketamine HCL was extremely less compared with the former Ketamine intramuscular administration method, especially for the high risked patients. In case of the patients applied with the combination use of Ketamine HCL and relaxant, the total dose of Ketamine could be reduced remarkably.