Abstract
A number of transplantable animal models of osteosarcoma have been developed so far, but the available strains of the rat that keep their bone-forming ability through many serial transplantations are limited both in the number of strains and their applicability. In the present examination, the establishment of appropriate rat models for human osteosarcoma is attempted.Four kinds (A3, C5, D16, E3) of F344 rat osteosarcomas of bone-forming types induced with 4-NQO and 32P were transplanted into the medullary cavity of the tibia, the thigh muscle and the dorsal subcutaneous tissue of the hack of the same species for many generations, respectively. Three kinds (A3, D16, E3) of them could be serially transplanted in the subcutaneous tissue, with 100% success rate over 60, 45, and 30 passage generations, respectively. Histologically, during serial transplantation, tumor A3 gradually decreased in bone forming activity and became chondroblastic after the 40th generation. Tumor D16 also gradually decreased in bone formation and became fibroblastic after the 45th generation. However, tumor E3 continued to possess bone forming activity after 30 generations.Because of these three strains of osteosarcoma having different characteristics in transplantability and histology, it is thought to be of great value in the investigating osteosarcoma of human being and bone metabolism.
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