Abstract
To study the feasibility of employing cefodizime (CDZM) in the field of oral surgery, a pharmacokinetic analysis was performed for CDZM concentrations in the oral tissues after intravenous injection of 1g CDZM in 26 patients.The following results were obtained:1) The half-life of CDZM in serum was calculated to be 2.64 hours.2) The peak concentrations of CDZM were 13.03 μg/g in the gum, 4.84 μg/g in the bone and 17.06 μg/g in the cyst wall. The AUC of CDZM in oral tissue to that in serum was 12.53% in the gum, 3.26% in the bone, and 8.23% in the cyst wall.
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More From: Japanese Journal of Oral & Maxillofacial Surgery
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