Abstract
Only few studies on the relationship between vitamin D3 and platelet functions have been described. We studied the effects of 1α, 25-dihydroxyvitamin D3 [1α, 25(OH)2 D3] on aggregation of platelet rich plasma (PRP) from wistar rats. Collagen-induced aggregation in PRP was inhibited for 1-12 hours after the administration of 1α, 25(OH)2 D3, while there was no inhibition of ADP-induced aggregation in PRP. Inhibited platelet aggregation recovered to normal after 16 hours from administration and correlated with the dosage of 1α, 25(OH)2 D3 administrated. Serum 1α, 25(OH)2 D3 of the rats studied and MDA production were also determined. There was a good relationship between the serum of 1α, 25(OH)2 D3 and inhibition rate of platelet aggregation, but there was no change of MDA production after the administration of 1α, 25(OH)2 D3.These results show that 1α, 25(OH)2 D3 transiently inhibited platelet aggregation induced by collagen. The mechanizm of aggregation inhibition remains to be clarified.
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