Новая классификация цитомегаловирусного ретинита

Abstract

Purpose. To present a new classification of cytomegalovirus retinitis (CMVR). Material and method. 48 patients (86 eyes) with CMVR after transplantation of hematopoietic stem cells. Ophthalmoscopy of the posterior segment of the eye with mydriasis, the introduction of an antiviral drug into the vitreal cavity with intraocular fluid sampling from the anterior chamber were performed once a week until complete elimination of cytomegalovirus copies from aqueous humor. Results. Data were obtained that allow us to state that the probability of achieving CMVR remission by the next visit is inversely proportional to the actual results of aqueous humor polymerase chain reaction and achieving remission by the next visit is impossible if there are two or more thousand copies of cytomegalovirus in aqueous humor. Conclusion. The proposed classification suggests a decision-making algorithm: in the presence of copies of the virus in the moisture of the anterior chamber –to carry out intravitreal injections of antiviral drugs, with the growth of CMV copies in the intraocular fluid –to change the drug for intravitreal administration and stop the series of injections when a negative result of the watery polymerase chain reaction is reached. moisture. Keywords: cytomegalovirus retinitis, children, classification.