Abstract
Objectives : Phyllostachys Folium is leaves of Phyllostachys nigra var. henesis <TEX>$S_{TAPF}$</TEX>. In the East Asian traditional medicine, the herb has been used to treat nasal bleeding, dysuria, epilepsy and etc. The present study was conducted to evaluate the anti-inflammatory effects of the Phyllostachys Folium water extracts (PFE) in vitro and in vivo model. Methods : Cell viability was measured by MTT assay after the treatment of PFE and NO production was monitored by measuring the nitrite content in culture medium. iNOS, COX-2, <TEX>$I{\kappa}B$</TEX>, <TEX>$p-I{\kappa}B{\alpha}$</TEX> amd <TEX>$NF{\kappa}B$</TEX> were detected by immunoblot analysis, and levels of cytokine were analyzed by sandwich ELISA kit. Anti-edema effect of PFE was determined in the carrageenan-induced paw edema model in rats. Results : LPS increased NO and cytokines levels compared with control, these increases were attenuated by PFE. In addition, LPS-induced pro-inflammatory proteins such as iNOS, COX-2 were down regulated by PFE. These anti-inflammatory effect of PFE results from inhibition of phosphorylation of <TEX>$I{\kappa}B$</TEX> and translocation of <TEX>$NF-{\kappa}B$</TEX>. Conclusion : These results show that PFE has some anti-inflammatory effects which might play a role in gram-negative bacterial infection inflammation and <TEX>$NF{\kappa}B$</TEX> activated diseases.
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