過去８年間のエナメル上皮腫，腺様歯原性腫よう，歯原性線維腫の臨床的，病理組織学的ならびに免疫組織化学的検討

Abstract

A clinical and histopathological report was made on 26 cases of ameloblastoma, 1 case of adenomatoid odontogenic tumor and 2 cases of odontogenic fibroma over a period of 8 years. The results were as follows;1. As for ameloblastoma, 23 among the 26 cases were primary and the remaining 3 were recurrent. No case was malignant. The following study was made on 15 well-documented cases.2. 12 among the 15 cases were primary and the remaining 3 recurrent. 14 cases involved the mandible and 1 case the maxilla. As for the 12 pimary cases, the age of the patients ranged from 11 to 73 years old. The average age was 35.6 years. 10 cases were male and 5 female. A wider excision than that appeared necessary from the roentgenograms was carried out in the 15 cases. No sign of recurrence has so far been found in any of them.3. According to the WHO classification, our series could be divided into 4 histopathological types; follicular type (4 cases), prexiform type (6 cases), acanthomatous type (3 cases) and mixed type (2 cases).4. A575 antibody (DAKO) to keratin produced a brown coloration of the parenchyma in all 15 cases. SE and NSE antibodies (Lipshaw) to keratin showed a positive reaction of the parenchyma in 13 cases. The degree of the reaction seemed to be stronger for NSE antibody than for SE antibody. These results indicate that ameloblastoma is an epithelial tumor and its epithelial components closely resemble those of simple epithelium.5. A 33-year-old female was histopathologically diagnosed as having an adenomatoid odontogenic tumor. After extirpation, no sign of recurrence has been found. A575 antibody produced a positive coloration of the parenchyma. The reaction for EMA was slightly detectable in the parenchyma. These results indicate that adenomatoid odontogenic tumor is an epithelial tumor and its epithelial components closely resemble those of glandular epithelium.6. A 31-year-old male (Case 1) and a female (Case 2) were histopathologically diagnosed as having odontogenic fibroma. After extirpation, no sign of recurrence has been found. A575 and NSE antibodies produced a positive reaction in Case 1, and A575, SE and NSE antibodies produced a positive reaction in Case 2. These results indicate that odontogenic fibroma is an epithelial tumor.