Abstract
Research & Development Center, Dongwon F&BAbstract The principal objective of this study was to produce a chitosan nanoparticle (NP) system for improving bloodcirculation. Chitosan NPs were prepared using fucoidan and poly-γ-glutamic acid (PGA), denoted as CS/Fu and CS/Fu/PGA NPs, respectively. As the chitosan concentration was increased, the activated partial thromboplastin time (APTT) ofthe NPs significantly increased (p<0.05). When the concentration of fucoidan and γ-PGA was 5-20 and 1-10µg/mL,respectively, the size of the CS/Fu and CS/Fu/PGA NPs was approximately 200 and 100 nm, respectively. With an increasein the fucoidan and PGA concentration, the APTT of CS/Fu and CS/Fu/PGA NPs significantly increased (p<0.05). Theseresults suggest that CS/Fu and CS/Fu/PGA NPs could be used as a potent NP system for improving blood circulation.Keywords: blood circulation, activated partial thromboplastin time, nanoparticle, chitosan
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