Abstract
The resistance of house mice (M. musuclus linnaeus, 1758) and norway rats (R. norvegicus berkenhout, 1769) to anticoagulants of the 1st and 2nd generation in the VKORC1 gene in Moscow and the Moscow region was studied. House mice had two previously unknown mutations in exon 1: Lys175Arg и Ser94Trp. We assume that these mutations can increase the resistance of rodents to second-generation anticoagulants. the percentage of individuals with mutations in exon 1 in Moscow is 87.5 %, in Noginsk and Podolsk – 100 %. Of the 18 norway rats studied in Moscow, only three individuals in a heterozygous state were found to have one of the mutations (Tyr139Ser), usually associated with genetic resistance of rodents to the first generation anticoagulant warfarin. the percentage of resistant individuals in Moscow was 15.7 %. the rats in which the resistance mutation was found were captured in three districts of moscow: southwestern, northern and eastern.
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