Особенности персистенции нетифоидных сероваров Salmonella enterica в эпителиальных клетках и макрофагах

Abstract

Mode of persistence in host cell of nontyphoid serotypes (NTS) of Salmonella enterica depends on the type of host cell. In epithelial cells NTS possess bephase life cycle. They possess ability to evade from salmonella containing vacuole into cytosole, where they begin to cause hyperreplication. In epithelial cell of intestine the large number of replicated NTS are extruded into the lumen of the intestine. Cytosole of macrophages is non permissive for NTS replication. Nonreplicating population of persisters which are tolerant to antibiotic are formed immediately after uptake by macrophages It is proposed that toxin-antitoxin modules promote formation of persister. Intra macrophages NTS reprogram its metabolism forming more beneficial environment for persistence Key words: nontyphoid serotypes of S. enterica, bephase life style, epithelial cell, macrophages, persister, module toxin-antitoxin