Abstract
PURPOSE: The purpose of this study was to investigate the effect of prolonged exercise and fasting on PPAR isoforms(PPARα & PPARγ1) in rat skeletal muscle.<BR> METHOD: Thirty-six male rats (Sprague-Dawley) were assigned to one of three subgroups: control (n=12), fasted (n=12), exercise (n=12). Rats treated swimming exercise (2hr; 30 min × 4) and fasting (18hr). We measured PPAR isoforms content(PPARα & PPARγ1), liver glycogen, glucose, FFA concentration. All data are presented as means±SD. Date were analyzed with one-way ANOVA, post hoc analysis was perfo rmed to determine using Tukey’s post hoc test. Singificance was set at P＜.05.<BR> RESULTS: In fasted rats, liver glycogen concentration significantly decreased compared to control (P＜.001) and exercisee (P＜.01). Despite the increases in the FFA level both exercise and fasting, there was no significant changes were detected in PPARα & PPARγ1 protein content in soleus muscle (P＞.05).<BR> CONCLUSIONS: Collectively, these results indicate that PPARα & PPARγ1 protein unaffected by both exercise and fasting and/or elevated in FFA concentration. Further studies are required to determine intert issue communication during combined fasting and exercise.
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