카테킨 섭취와 지구성 운동이 Obese Zucker Rat의 골격근 형태별 GLUT-4 단백질과 혈청 지질 성분에 미치는 영향

Abstract

Obesity and diabetes have been increased at an alaming rate in recent years and is now a worldwide health problem. We investigate the effects of 8wk feeding tea catechin which is natural polyphenolic compounds and 8wk treadmill exercise on the skeletal muscle GLUT-4 protein, serum glucose, insulin and lipids(TC, TG, HDL-C, LDL-C) in the insulin resistant obese Zucker rats(fa/fa). Male obese Zucker rats either remained sedentary(fa/fa, n=4), recieved catechins(5㎖=2.5g/250㎖(1%) day-1, fa/fa, n=4), performed treadmill exercise(fa/fa, n=4) or underwent both catechin supplementation and treadmill exercise(fa/fa, n=4) for 8wk. During oral glucose tolerance test(OGTT), treadmill exercise alone or in combination with catechins resulted in a significant lowering of the glucose, insulin and TC, TG, LDL-C responses compared with sedentary controls. Treadmill exercise or in combination with catechin group individually increased insulin-regulated glucose transporter(GLUT-4) in isolated soleus, plantaris and gastrocnemius muscle. The greatest expressions in GLUT-4 protein in these muscles were observed in the treadmill exercise group. Thus, enhancement in glucose transport in soleus, plantaris and gastrocnemius muscle due to treadmill exercise and in combination with catechin was related to enhanced GLUT-4 protein and decrease glucose, insulin and TC, TG, LDL-C. These results suggest that treadmill exercise and in combination with catechin individually may reduce the risk of associated diseases including diabetes and coronary heart disease.