Abstract
Fat is a good energy source and plays an important role in healthy cells, brain function, and cardiovascular health. Drone pupae are rich in fat and composed of various fatty acids. This study investigated the effects of drone pupa fat extract on inflammatory responses in skin cells. After inducing an inflammatory response in HaCaT cells using IFNγ, the effects of drone pupa fat extract on the expression of cytokines and chemokines, which are cell signaling molecules were examined. Changes in the expression of 25 out of 105 signaling molecules were inspected. The detected molecules are involved in wound healing, cell regeneration, and antimicrobial production. These results are expected to be used as industrial materials to protect human skin from harmful environmental effects.
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