О механизме термического разложения D-циклосерина и теризидона

Abstract

The article studies the mechanism of thermal decomposition of two drugs from the group of isoxazolidines D-cycloserine, and terizidone, potentially exposed to the action of elevated temperatures in production (preparation and drying stages). As a result of series of the analytical experiments on the study of solid products of samples thermal decomposition by IR spectroscopy, including with the participation of a comparative sample (more thermally stable nootropic drug fonturacetam), it was established that the antibiotics D-cycloserine and terizidone containing in their molecular formula a five-membered heterocycle with the [–C–O–N–] group (absorption band in the area of 1461 cm–1) have low thermal stability associated with the ease of breaking N–O bond. It is noted that at the maximum degrees of decay, the specified absorption band weakened until it completely disappeared. The obtained results on thermal decomposition, apparently, can be interpolated to all the substances having specified heterocycle in the structure, which is explosiphoric. Before launching into production, when modeling substances with the specified pharmacological properties, it is required, if possible, to avoid structures with a similar heterocycle with a choice of more heat-resistant analogues that are not inferior in efficiency. Such solutions to reduce fire hazard at the stage of development of technological processes seem to be the most efficient. The study results confirming the propensity of the studied compounds to thermal decomposition at relatively low temperatures contributed to the creation of a safe technological process, storage and transportation conditions at the place of production of FGUP «GNTs «NIOPIK».