Abstract
This review covers the published papers describing endothelial dysfunction pathogenesis and molecular mechanisms behind the effect of low-level laser therapy on regulation of the said pathogenesis. Herein, we present the current experience of using laser therapy to prevent development of endothelial dysfunction in the context of post-COVID-19 rehabilitation, as well as the accumulated data on the methods of combination of external or intravenous laser blood therapy and influence on the immunocompetent. We provide justification for practicing personalized approach at various stages of post-COVID-19 rehabilitation and treatment. The basis allowing greater efficacy of post-COVID-19 rehabilitation, including protocols making use of laser therapy, is the analysis of single-nucleotide polymorphisms of genes that determine adaptation processes, peculiarities of the immune response to infectious pathogens, predisposition to the development of respiratory distress syndrome, severe pneumonia, sepsis, multiple organ failure, development of endothelial dysfunction, thrombotic complications, the analysis that allows identification of patients running higher risk of critical conditions.
Highlights
This review covers the published papers describing endothelial dysfunction pathogenesis and molecular mechanisms behind the effect of low-level laser therapy on regulation of the said pathogenesis
The global COVID-19 pandemic caused by the SARS-CoV-2 coronavirus is a challenge for the entire mankind, but the first to search for solutions thereto are scientists and doctors that are tasked with finding ways to curb incidence, effectively treat and rehabilitate COVID-19 patients and minimize the associated complications and mortality
This literature review demonstrates the capacities of laser therapy in the context of endothelial dysfunction treatment
Summary
ENDOTHELIAL DYSFUNCTION IN COVID-19 PATIENTS AND CLINICAL APPLICATION OF LASER THERAPY. Long before the COVID-19 pandemic, significant individual characteristics of critical conditions observed dynamically triggered the analysis of the results of geno-phenotypic examinations of IC patients [15–19] These studies presented comorbid conditions gene diagnostics, identified SNP markers associated with an increased risk of community-acquired and nosocomial pneumonia, risk of development of an acute respiratory distress syndrome, CVD-related thrombotic complications. The results of the analysis of identified gene polymorphisms the products of which shape regulation (hemostasis, renin-angiotensin system regulation, immune system regulation, i.e. individual response to infectious pathogens and production of cytokines, drug metabolism) provide justification to screening patients running a high risk of development of life-threatening conditions Such patients need non-standard treatment approaches in critical situations. Despite the fact that the regulation mechanisms are known (see Table 1), the ways to remedy endothelial dysfunction pharmacologically require further comprehensive study and
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