Особенности фекальной микробиоты при Clostridioides difficile- ассоциированной инфекции

Abstract

Aim. Study of the dynamics of changes in the intestinal microbiota of patients with Clostridioides difficile-associated infection. Materials and methods. The study included 746 patients in inpatient treatment. 502 patients were examined at the stage of admission and discharge from the hospital, and 305 patients with the clinical picture of Clostridioides difficile-associated infection (CDI), among them 163 (46.6%) men and 142 (53.4%) women. The age of the patients was 48-67 years. The qualitative and quantitative composition of translucent feces was investigated. Results. Analysis of the study of the qualitative and quantitative composition of the fecal microbiota of patients treated in a coloproctology hospital and patients with a clinical picture of Clostridioides difficile-associated infection showed the dynamics of changes in the colonic microbiota in patients upon admission to hospital and the development of the clinical picture of antibiotic-associated diarrhea. Upon admission to the hospital, patients with diseases of the colon showed a decrease in the titer of lactobacilli (median 10 * 5 CFU / g., Fluctuation range 10 * 4 CFU / g; 10 * 6 CFU / g). With colitis caused by Clostridioides difficile and other members of the genus Clostridium spp., A significant decrease in the amount of lactobacillus in the luminal feces was observed (p <0.01). There were no significant differences in the level of contamination of the luminal feces with enterobacteria in all groups of patients examined. Conclusions. Development of CDI is characterized by a pronounced decrease auhtonnoy microflora, especially lactobacilli. The degree of microbiota changes in patients with CDI is ambiguous for each member of the microbial community of colonic microbiocenosis.