Abstract
Ferroptosis is a form of programmed cell death associated with iron-dependent lipid peroxidation. Novel ferroptosis inducers and suppressors could be instrumental in developing drugs against neurodegenerative disorders and cancer. Prior to embarking on a search for ferroptosis inducers/suppressors, this form of cell death must be studied in living cells and laboratory animals. In addition to two cofactors, luciferase (or photoprotein) of the parchment tubeworm Chaetopterus variopedatus requires the presence of iron ions and hydrogen peroxide or organic hydroperoxides to exert its activity. Therefore, the bioluminescence system of the parchment tubeworm can be used to study ferroptosis in living organisms.
Highlights
OPINION CELL BIOLOGYShcheglov AS , Tsarkova AS Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia Pirogov Russian National Research Medical University, Moscow, Russia
Erastin directly interacts with mitochondrial voltagedependent anion channels (VDAC) and its action is inhibited by antioxidants, such as α-tocopherol, butylated hydroxytoluene and β-carotene [4]
The loss of glutathione peroxidase 4 (GPX4) activity leads to iron-dependent lipid peroxidation and the accumulation of lipid hydroperoxides in the cell, resulting in ferroptotic cell death [5, 7]
Summary
Shcheglov AS , Tsarkova AS Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia Pirogov Russian National Research Medical University, Moscow, Russia. С. Царькова Институт биоорганической химии имени М. А. Овчинникова, Москва, Россия Российский национальный исследовательский медицинский университет имени Н.
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