Ефективність застосування препарату Магнефар В6 в акушерській практиці

Abstract

The objective:: to conduct a comparative assessment of the Magnefar B6 application effectiveness and safety in pregnant women with other magnesium salts drugs in the aspect of obstetric and perinatal complications frequency reduction. Materials and methods. А comprehensive examination of 60 pregnant women was carried out. 30 pregnant women took medication Magnefar B6 in a daily dose of 1500 mg of magnesium asparaginate and 15 mg of pyridoxine hydrochloride (main group) and 30 who took medications of other magnesium salts group (comparison group). Symptoms of magnesium deficiency were determined by questionnaire. The analysis of the clinical course of the first half of the pregnancy with the determination the frequency and structure of complications, blood pressure levels, indicators of ultrasound, general and biochemical blood tests, urinalysis, lipid status and carbohydrate metabolism, hemostasis, immune system, depending on the drug that was used to restore the balance of magnesium was conducted. Results. Conducted survey revealed the state of magnesium deficiency in all pregnant women at the present stage. The main complications of the first half of pregnancy were: threatening miscarriage; abortion in progress; missed pregnancy; early gestosis; anemia; respiratory viral infection; exacerbation of extragenital pathology; hypertension. During the analysis of carbohydrate and lipid metabolism as well as hemostatic system, T– and B-cell component of immunity in pregnant women with hypomagnesemia insulin resistance condition, increased atherogenic potential, the initial manifestation of hypercoagulation condition, an imbalance of immune cells at the system level were detected. Conclusion. Correction of chronic magnesium deficiency using medication Magnefar B6 provided a reduction in the frequency and severity of complications of pregnancy, leaded to the normalization of blood pressure, carbohydrate and lipid metabolism, hemostasis system, T– and B-cell immunity. Key words: magnesium deficiency, pregnancy complication, Мagnefar B6.