Abstract
Polymorphous low-grade adenocarcinoma (PLGA) appears at a markedly higher frequency in the palate than at other locations. It is often misdiagnosed because of its infrequency and deceptively bland histological appearance. It is sometimes especially difficult to distinguish between PLGA and adenoid cystic carcinoma when there are overlapping histologic features. Here, we describe the immunohistochemical characterization of PLGA arising in the palate. The wide range of PLGA immunohistochemical findings was analogous to histological polymorphism. The components of PLGA definitely showed myoepithelial characteristics, as shown by the immunohistochemical expression of epithelial markers (cytokeratin and epithelial membrane antigen), vimentin, and S-100 protein.
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