Abstract
The question of whether pulsing electromagnetic fields (PEMF) can influence the bone metabolism, especially the epiphyseal plate, in growing animals and men, is still unanswered. In this study, PEMF was applied to growing mice treated with a high dose of 1-hydroxye-thylidine-1, 1-bisphosphonate (HEBP, 40mg/kg/day) for 4 weeks. PEMF consisted of 15Hz repetitive pulse burst, that is, 228μs pulse width and 5ms burst width. HEBP inhibited the mineralization of cartilage and bone, namely, there was a widening of the epiphyseal plate which is comprised mainly of proliferating cells and an increase of osteoid on the metaphysis. Histologically, between the HEBP group and the HEBP+PEMF group, no significant changes were observed in the lumbar spine and distal end of the femur.
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