Abstract
We have developed a computer program (PPMODELS) for the analysis of the physiological pharmacokinetic model in a changed physiological condition by using NeXTSTEP 3.0J. The software was designed to facilitate the process of generating patient-specific drug doses using physiological and biochemical parameters.System architecture provides an object-oriented and graphical user interface (GUI) within a Windows environment that will link image processing, spreadsheet, text, and graphics software packages into a single operational environment. The software uses the Runge-Kutta-Gill algorithm to approximate numerically the solution curves. The initial values, schedules and routes of administration can be defined on the spreadsheet.The plasma, brain and adipose tissue biperiden concentrations were simulated by the PPMODELS using the physiological parameters after repeated administration of 3.88 mg of biperiden intramusculary to the patient. This work demonstrates that this program can be a useful tool for simulating the drug disposition in conjunction with the physiological pharmacokinetic model.
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