前立腺肥大症に対するｍｉｃｒｏｗａｖｅ ｔｉｓｓｕｅ ｃｏａｇｕｌａｔｏｒ（ＭＴＣ）を用いた高温度治療の開発

Abstract

Eight male beagle dogs (12-24 months of age, 10-18 kg body weight) were used in this study. All dogs were castrated and then administered 5a-androstane-3α, 17β-diol (3α-diol) plus 17β-estradiol (estradiol) for 24 weeks according to Walsh and Wilson's method. Microwave needle ablation of the prostate using microwave tissue coagulator (MTC) was performed the dog when its prostate become over 25 mL in volume. At the experimental day, 1w, 4w, 12w, dogs were slaughtered and the prostate was harvested. Bladder and external sphincter samples demonstrated no gross abnormalities. Microwave needle ablation can ablates rapidly and constantly. The range which microwave reaches is always exact. The needle position and extend of ablating can be revealed with transrectal ultrasonography. We performed microwave needle ablation of the prostate using MTC to one BPH patient who got his consent. His episode of care was good. The immediate goal is to obtain the fundamental data, and to verify the clinical availability of microwave needle ablation for the treatment of BPH and localized prostate cancer.