Abstract
The objective of this research was to demonstrate the applicability of PLGA nano-spheres for transdermal drug deliveries. By applying spherical crystallization with emulsion solvent diffusion method in an aqueous PVA solution, the pro-vitamin C loaded and the coumarin-6 loaded PLGA nano-spheres with an average particle size of 215nm were prepared and tested via the human skin biopsies in a modified Bronaugh diffusion chamber. The coumarin-6 loaded PLGA nano-spheres showed excellent capability of passing through skin pores and had a superior cutaneous penetrability to deep-epidermis, both in speed and quantity compared to the coumarin-6 dispersion liquid at a much higher concentration.The pro-vitamin C loaded PLGA nano-spheres were also found to be much more effective in supplying reduced vitamin C to deep-skin than pro-vitamin C emulsion. In addition, the PLGA nano-spheres could prolong the retention of reduced vitamin C for better skin care results. Furthermore, inhibitory effects of pro-vitamin C loaded PLGA nano-spheres on DNA double-strand breaks by UV-A and UV-B irradiations were confirmed.The PLGA nano-sphere was proven to be a viable vehicle for transdermal drug delivery application.
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