Abstract
Animal testing for toxicity assessments has long been a point of contention due to concerns over animal welfare and ethics. As an integral component of product development and consumer safety, the evaluation of chemical toxicity is vital. Yet, the 21st century has witnessed a growing demand for alternative testing methods that can offer sustainable solutions without relying on animal experiments. This need has spurred major developed countries and international standardization organizations to pursue the development and standardization of novel testing approaches. Among these, organoid-based methods have emerged as a promising avenue for innovation.
 This study examines the concept of organoids, defining and categorizing alternative testing methods. It explores a broad spectrum of topics, including the standardization trends of alternative testing method regulations, organoid-based method standardization, and trends led by government entities, research institutions, academia, and corporations. It also examines the development of organ-specific manufacturing protocols for organoids. The research finds that international efforts to standardize alternative testing methods are in progress, with a particular focus on organoid-based strategies.
 The anticipated growth and evolution of such alternatives could revolutionize standard practices in safety assessments and drug efficacy evaluations. The standardization of organoid-based testing methods is poised to become a crucial milestone in advancing human health and environmental protection, driving the sector's growth and innovation. Moreover, advancements in organoid technology and the creation of models for various organs are likely to further refine alternative testing methods and introduce new evaluation techniques for drugs and chemicals. This study highlights to the biomedical community that standardizing new testing methods can address the ethical dilemmas of animal testing, underscoring a significant contribution towards ethical scientific practices.
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