Abstract
Department of Science and Technology Education for Life, Seoul National University of EducationAbstract Saccharin was reported to cause urinary bladder cancer in male rats when fed at high doses in a two-generationstudy, which led to a ban on the use of saccharin in Canada. However, no carcinogenic effect has been observed in otheranimal experiments conducted with mice, hamsters, or monkeys. Furthermore, numerous epidemiological studies haveindicated that there was no relationship between saccharin consumption and the risk of bladder cancer in the humanpopulation. Sodium saccharin produces urothelial bladder tumors in rats by the formation of a urinary calcium phosphate-containing precipitate, which is not relevant to humans because of critical interspecies difference in urine composition.Consequently, in 1999 IARC (International Agency for Research on Cancer) concluded that saccharin and its salts cannotbe classified as to their carcinogenicity in humans. In 2010, the EPA (Environmental Protection Agency) of the UnitedStates removed saccharin from its list of hazardous substances. It is expected that the use of saccharin in foods might beexpanded because saccharin is currently considered safe.Keywords: saccharin, sodium saccharin, artificial sweetener, safety
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