タンパク質結晶構造解析入門―ブラックボックスの中身―（３）モデリングの裏側をのぞいてみよう 位相改良による電子密度図のリファイン

Abstract

Before starting model building, the first set of protein phase, which is obtained with the isomorphous replacement method, the multiple wavelength anomalous dispersion method, and/or the molecular replacement method, should be improved by the phase improvement and density modification techniques. An insufficient quality of the electron density map might be a snag for model building. Methods of phase improvement and density modification techniques must usually be performed.