Abstract
Glu-and Lys-plasminogen (plg) were subjected to low pH (pH 2.0). Their conformation and activation rates were measured. The activtaion rates of Glu-plg enhanced after acidified. The increase was irreversible even after a short interval of acidification. The activation rate of acidified Glu-plg did not increase in the presence of fibrin or fibrinogen. The activation rate of acidified Lys-plg rather decreased and was not influenced in the presence of fibrin or fibrinogen. The fluorescence intensity at 340nm of plasminogen decreased after acidification. The negative molar ellipticity, [Θ], of Glu-plg decreased after acidification but that of Lys-plg did not change.These results indicate that the conformational change corresponded to the increased activation rate of Glu-plg after the acidification. Although the tertiary conformation of Lys-plg changed after the acidification, its activation rate did not change.
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