Abstract
Platelets play a crucial role in hemostasis, participate in immune response, inflammation, angiogenesis and tissue regeneration. On the other hand, platelets can actively participate in different pathological processes including tumorigenesis. Platelets can directly interact with cancer cells in circulation and contribute to metastasis, tumor angiogenesis and outgrowth. During the last few decades a large amount of data concerning platelet engagement in cancer progression was accumulated. These data require thorough analysis and systematization in view of the fact that even though platelets can be involved in cancer development and metastasis due to their physiological characteristics their role can be exaggerated. In this review, interplay between platelets and cancer is discussed. In addition, we provide an insight into platelet-targeted pharmacologic approaches to cancer treatment and their limitations, as well as the potential role of platelets and platelet microparticles in innovative therapeutic approaches.
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