プラズマ照射した医薬品助剤を利用する新規なドラッグデリバリーシステムの開発 第１０報 スチレン‐（無水）マレイン酸共重合体を外層高分子とした二重錠剤へのプラズマ照射によるテオフィリンの放出制御

Abstract

As a part of the development of the DDS device using plasma-irradiated polymer, the utility of poly(styrene-maleic anhydride) (SMAn) and poly(styrene-maleic acid) (SMA) was investigated. From the results of plasma degradation tests and the electron spin resonance (ESR) studies on plasma-irradiated SMAn and SMA, it was found that they were of intramolecular bifunctionality, cross-linkable phenyl group and degradable maleic anhydride or maleic acid group as an effect of plasma irradiation. Using these plasma characteristics, controlled-release tablets were designed by argon plasma irradiation on the outer layer of double-compressed tablet prepared from theophylline as a core material and SMAn or SMA as a single wall material. The dissolution profiles of theophylline from plasma-irradiated double-compressed tablet were sufficiently modified in comparison with one of non-plasma-irradiated tablet, depending on the set of chosen plasma operational conditions.