Abstract
Dyslipidemia is a conventional risk factor for atherosclerosis and is observed in most rheumatic diseases, which leads to a high cardiovascular risk in patients with autoimmune pathology. The review considers the main aspects of cholesterol metabolism associated with dysfunction of monocytes and macrophages in autoimmune rheumatic diseases. The study of the pathogenetic mechanisms of cholesterol metabolism in chronic inflammatory diseases is of great fundamental and clinical importance, since it allows the development of new diagnostic algorithms and therapeutic approaches to reduce cardiovascular risks in these patients. Moreover, it can be used for creating alternative strategies to modify the functions of the immune system. Keywords: cholesterol metabolism, dyslipidemia, macrophages, inflammation, autoimmune diseases
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