전기방사를 사용한 항균성 컬큐민 함유 Zein 나노섬유의 제조

Abstract

Electrospinning was used to load curcumin (a natural compound that has antiinflammatory properties) into zeinnanofibers. An emulsifier, Tween 80, was combined with curcumin in the zein nanofibers. The morphology of the curcumin-loaded zein nanofibers (CLZNFs) was observed using field emission scanning electron microscopy. Investigationof curcumin released from the zein nanofibers into phosphate buffer saline at pH 7 indicated that the Tween 80 hadincreased the amount of curcumin released from the CLZNFs. The antibacterial activity of the CLZNFs against Staphylococcusaureus (S. aureus) was determined by measuring the optical density of bacterial solutions containingCLZNFs. The zein nanofibers fabricated with 10 wt% surfactant and 1.6 wt% curcumin showed high (i.e., 83%) efficiencyin inhibiting the growth of S. aureus in the solution incubated for 21 h. These results suggest that the electrospunCLZNFs show potential application as antibacterial nonwoven mats.