유색미 겨 아라비녹실레인과 지구성 운동트레이닝이 LPS 처치된 흰쥐의 TLR4 Signaling 단백질 발현에 미치는 영향

Abstract

Abstract The purpose of this study is to investigate the effects of arabinoxylan rice bran and endurance exercise training on TLR4 mediated protein expression in LPS-treated rats. The results showed that TLR4 as an important protein in the inflammatory response against lipopolysaccharide was shown to be significantly lower in both arabinoxylan supplement with exercise group and exercise group, thus the arabinoxylan rice bran had a higher inhibitory activity than arabinoxylan supplement group. However, NF-κB and MyD88 protein expression was not changed in arabinoxylan supplement with exercise training group, whereas NF-κB significantly decreased in 4 weeks of exercise training group. These results suggest that the supplement of arabinoxylan rice bran with exercise is likely to contribute to inflammation response and the arabinoxylan rice bran can be used as a possible safe alternative to the immunotherapeutic intervention. Key words: arabinoxylan, TLR4, inflammatory response Corresponding