Оценка гепатопротекторной активности «Гексафита» при D-галактозаминовом гепатите, антиоксидантной активности препарата и его ингредиентов

Abstract

The expansion of research to find sources for obtaining new effective and safe medicines of plant origin, including those used in gastroenterological practice, is a pressing task of medical science, considering that the range of medicinal plant drugs used in practical health care is more than 40%. The results of the biochemical study of the hepatoprotective and choleretic activities of a Hexafite multicomponent extract obtaining from following types of raw materials: flowers of Helichrysum arenarium L. and Tanacetum vulgare L., fruits of Rosa sp., leaves of Urtica dioica L. and Mentha piperita L. and radices of Glycyrrhiza glabra L. were received. It is established that Hexafite per os administration of dose of 250 mg/kg to non-linear white rats with D-galactozamine induced liver injury has hepatoprotective and choleretic effects, exceeding Allocholum effect by some data. Pharmacotherapeutic effect of the extract in model of liver injury is due to the presence in it of a complex of biologically active substances, primarily compounds of phenolic nature. The inhibitory effect of Hexafite on free radical oxidation of lipids, stabilization of the biological membranes of liver cells with a subsequent increase in the functional activity of the liver is provided due to their dominant content. The obtained research results argue the expediency of the use of Hexafite containing biologically active substances of a phenolic nature in the prevention and treatment of liver diseases. It is shown that the collection of bile action and the plants included in it have antioxidant activity in vitro. The experiment revealed a synergistic effect on the manifestation of the total antioxidant activity of the collection.