Abstract
Experiments with cats showed that new 3-hydroxypyridine derivative IBKhF-27, mexidol and melatonin, and combination of IBKhF-27 with melatonin and mexidol affected directly 84.8; 67.8; 77.4; 97.9 and 88.1 % neurons of the 1st vestibular zone of the cerebral cortex, respectively. Inhibition by IBKhF-27 was observed 1.4 times more often than by mexidol. Combinations of IBKhF-27 with melatonin and mexidol produced the inhibitive effects on neurons oftener than each component separately; the direct effect of IBKhF-27 with melatonin occurred oftener than each of these two components separately. Also, the inhibitive effect of IBKhF-27 with melatonin was seen more often than of melatonin combined with mexidol. In the presence of MK-801, specific noncompetitive antagonist of the NMDA-receptor complex and luzindol, specific antagonist of melatonin MT1- and MT2-receptors (before pneumomicroinjection dosages), the direct effect of IBKhF-27 with melatonin or mexidol on the spontaneous activity of neurons was prevented fully or attenuated materially in 95.3 and 88.2 % neurons, respectively. Consequently, 1st vestibular zone of the cerebral cortex has a great role in the central action of these combinations executed fully or partly through the NMDA-receptor complex and melatonin MT1-, MT2-receptors.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
