Abstract
This study examines the effect of anticoagulant and antithrombotic drugs on blood pressure (BP), plasma renin activity (PRA) and renal glomerular and vascular lesions in malignant hypertensive rats. Whole-heparin, low molecular weight (LMW)-heparin, or defibrinotide were administered for 4 weeks to rats following complete aortitic legation between the renal arteries. BP and PRA in whole-heparin treated rats were significantly lower than those in control rats (p<0.001, p<0.001). Renal morphology also revealed a reduced number of epithelial cell droplets (ECD) in glomeruli and less severe vascular lesions (p<0.05, p<0.005). A decreased BP and PRA were seen in rats receiving LMW-heparin, but there was no improvement of vascular damage in this group.From these results, it was suggested that an increased anti-Xa activity or reduction of PRA is not enough to prevent these lesions in malignant hypertensive rats, and that antiinflammatory action or enhancement of negative electric potential of vascular wall included in whole-heparin also may contribute to prevent vascular damage. The rats receiving defibrinotide showed reduced BP only.
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