Abstract
The state of lipid peroxidation, non-enzymatic and enzymatic antioxidant protection in young calves with a symptom complex of diarrhea was investigated. It was shown that in the acute period of the disease, the content of serum lipid peroxidation products increases, the body's supply of antioxidants decreases, and the antioxidant protection enzymes superoxide dismutase and glutathione peroxidase of red blood cells are activated. It has been established that the intensity of the rapid chemiluminescence flash (ВI), which characterizes the presence of prooxidative factors in the serum, including lipid hydroperoxides, increased by the fifth day of the disease. At the same time, the light sum of chemiluminescence (∑i), which characterizes to a certain extent, the state of non-enzymatic antioxidant protection, has significantly increased. In the future, chemiluminescence decreases. By 15-25 days of life of animals, corresponding, according to clinical data, the recovery period, the values of ВI and ∑i did not differ from the initial level characteristic of the first day of life of calves. From the data obtained it follows that on the fifth day of the life of the calves, when the symptoms of the disease manifested themselves most vividly, the reliability of antioxidant protection decreased and the intensity of free radical lipid oxidation in the blood serum of calves diarrhea increased. The data are presented, the analysis of which showed that on the 15th day of life (1st group of calves) and on the 19th day (2nd group), the content of lipid hydroperoxides in the serum of sick calves increased almost 2 times relative to the level in healthy animals. At the same time, the peroxide resistance of erythrocytes, which reflects the availability of red blood cells and its body as a whole with antioxidants, significantly decreased. The obtained data allow us to consider the process of activation of free radical oxidation of membrane lipids as one of the mechanisms for the development of diarrhea in calves.
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